Avoid or Use Alternate Drug. Monitor Closely (1)lemborexant, doxepin. Mayo Clinic does not endorse companies or products. Minor/Significance Unknown. doxepin, fluphenazine. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Contraindicated. However, interactions are not common. Which antidepressant is best for you depends on a number of issues, such as your symptoms and any other health conditions you may have. Avoid or Use Alternate Drug. According to the FDA, diseases and medical conditions that are known to negatively interact with doxepin include: Please note that this list may not be complete, and there may be other diseases and medical conditions where patients should not take this medication. Avoid or Use Alternate Drug. Serious - Use Alternative (1)doxepin and ponesimod both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor. May cause increase or decrease in blood pressure. Minor/Significance Unknown. Modify Therapy/Monitor Closely. doxepin, sodium sulfate/potassium sulfate/magnesium sulfate/polyethylene glycol. pentazocine and doxepin both increase sedation. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor. All rights reserved. Use Caution/Monitor. stiripentol, doxepin. Monitor Closely (1)carbinoxamine and doxepin both increase sedation. Either increases toxicity of the other by pharmacodynamic synergism. lorazepam and doxepin both increase sedation. fesoterodine and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. and can have potentially adverse consequences. dipipanone and doxepin both increase sedation. Serious - Use Alternative (1)doxepin, vilazodone. Effect of interaction is not clear, use caution. Additive anticholinergic effects. Use lowest dose possible and monitor for respiratory depression and sedation. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. granisetron, doxepin. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Modify Therapy/Monitor Closely. Do not double the dose to catch up. Use Caution/Monitor. Monitor Closely (1)doxepin and pazopanib both increase QTc interval. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Disclaimer. The site is secure. Monitor Closely (1)doxepin and moxonidine both increase sedation. Avoid or Use Alternate Drug. The effects may be increased because of slower removal of the medicine from the body. oxybutynin transdermal and doxepin both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. It is important to tell your doctor about all other medications you use, including vitamins and herbs. This drug is available at a middle level co-pay. Additive anticholinergic effects. Monitor Closely (1)ipratropium and doxepin both decrease cholinergic effects/transmission. Effect of interaction is not clear, use caution. There are 27 disease interactions with doxepin which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. doxepin increases and modafinil decreases sedation. You may report side effects to Health Canada at 1-866-234-2345. Tetracyclic antidepressants. esketamine intranasal, doxepin. Use Caution/Monitor.doxepin and apomorphine both increase QTc interval. Monitor Closely (1)doxepin increases and metaproterenol decreases sedation. Minor/Significance Unknown. Minor/Significance Unknown. AUC and Cmax increased by 66% and 69% respectively. Use Caution/Monitor. Monitor Closely (1)carisoprodol and doxepin both increase sedation. Either increases effects of the other by sedation. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. ketamine, doxepin. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Monitor Closely (1)istradefylline will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. doxepin increases and diethylpropion decreases sedation. Avoid or Use Alternate Drug. Talk to your doctor or pharmacist for ways to improve your sleep without medication, such as avoiding caffeine and alcohol close to bedtime, avoiding daytime naps, and avoiding going to bed too early each night. Serious - Use Alternative (1)doxepin, metoclopramide intranasal. Use Caution/Monitor. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. verapamil increases levels of doxepin by decreasing metabolism. May lower seizure threshold; keep bupropion dose as low as possible. The recommended maximum number of medicines in the 'antidepressants' category to be taken concurrently is usually one. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Additive anticholinergic effects. Mechanism: unspecified interaction mechanism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. MedComm (2020). Use Caution/Monitor. Share cases and questions with Physicians on Medscape consult. Monitor Closely (1)methscopolamine and doxepin both decrease cholinergic effects/transmission. Infographic: Migraine Treatments: Botox & Nerve Blocking. Minor/Significance Unknown. procarbazine and doxepin both increase serotonin levels. Avoid or Use Alternate Drug. hyoscyamine spray and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. doxepin increases and salmeterol decreases sedation. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. solifenacin and doxepin both decrease cholinergic effects/transmission. Monitor Closely (1)doxepin and azithromycin both increase QTc interval. Monitor Closely (1)liotrix increases effects of doxepin by Other (see comment). Use Caution/Monitor. Use Caution/Monitor. Either increases toxicity of the other by sedation. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. Coadministration with drugs that increase serotoninergic effects may increase the risk of serotonin syndrome. Use Caution/Monitor. Please check with a physician if you have health questions or concerns. Monitor Closely (2)clozapine and doxepin both increase sedation. Use Caution/Monitor. Either increases levels of the other by pharmacodynamic synergism. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and imipramine both increase QTc interval. Antidepressants: Which cause the fewest sexual side effects? Minor/Significance Unknown. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. tramadol and doxepin both increase sedation. DrugGenius225 S. Mermac AveUnit 832TClayton, MO 63131. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Antidepressants and alcohol: What's the concern? Lower doses of drugs metabolized by CYP2D6 may be required when used concomitantly. Modify Therapy/Monitor Closely. Sometimes cyclic antidepressants are used to treat conditions other than depression, such as obsessive-compulsive disorder, anxiety disorders or nerve-related (neuropathic) pain. Avoid or Use Alternate Drug.Minor (2)doxepin, fluphenazine. Effect of interaction is not clear, use caution. Comment: Inhibition of uptake by adrenergic neurons. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Additive anticholinergic effects. Other (see comment). Continuously monitor vital signs during sedation and recovery period if coadministered. Minor/Significance Unknown. Minor (1)bazedoxifene/conjugated estrogens, doxepin. Which Insomnia Drugs Are More Effective and Have Fewer Side Effects? Use Caution/Monitor. perphenazine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. USES: This medication is used to treat a certain sleep problem (insomnia). imatinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. http://www.wolterskluwercdi.com/facts-comparisons-online/. Effect of interaction is not clear, use caution. Additive anticholinergic effects. Theoretical interaction. Minor/Significance Unknown. Either increases toxicity of the other by serotonin levels. Monitor Closely (1)doxepin and motherwort both increase sedation. Mechanism: unspecified interaction mechanism. Modify Therapy/Monitor Closely.Minor (1)sulfamethoxazole decreases levels of doxepin by unspecified interaction mechanism. doxepin and paliperidone both increase QTc interval. Also, increased appetite and weight gain were consistent side effects of doxepin relative to bupropion. health information, we will treat all of that information as protected health Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (3)doxepin decreases effects of lofexidine by unspecified interaction mechanism. Other (see comment). Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate increases effects of doxepin by unknown mechanism. information is beneficial, we may combine your email and website usage information with amoxapine and doxepin both increase serotonin levels. trazodone and doxepin both increase serotonin levels. Minor/Significance Unknown.doxepin, perphenazine. Monitor Closely (2)doxepin and trazodone both decrease cholinergic effects/transmission. midazolam intranasal, doxepin. Minor/Significance Unknown. Monitor Closely (1)cinnarizine and doxepin both increase sedation. ribociclib will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (2)stiripentol, doxepin. Monitor Closely (2)solifenacin and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Monitor Closely (2)doxepin and tapentadol both increase serotonin levels. clorazepate and doxepin both increase sedation. Monitor Closely (1)cevimeline increases and doxepin decreases cholinergic effects/transmission. Monitor Closely (2)doxepin and salmeterol both increase QTc interval. drug interactions checker>bupropion hcl oral and doxepin oral interactions. Avoid or Use Alternate Drug. National Library of Medicine Monitor Closely (1)doxepin and dihydroergotamine intranasal both increase serotonin levels. Monitor Closely (2)doxepin, lisdexamfetamine. View the formulary and any restrictions for each plan. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)doxepin and sorafenib both increase QTc interval. Minor/Significance Unknown. Use Caution/Monitor.Minor (1)desflurane, doxepin. henbane and doxepin both decrease cholinergic effects/transmission. doxepin, epinephrine. Use Caution/Monitor. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Use Caution/Monitor. It is in the tricyclic antidepressant class of medications. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages. Use Caution/Monitor. galantamine increases and doxepin decreases cholinergic effects/transmission. Use Caution/Monitor. doxepin and leuprolide both increase QTc interval. aclidinium and doxepin both decrease cholinergic effects/transmission. 2018 Aug 21;11:427-438. doi: 10.2147/DMSO.S171365. Pamelor (prescribing information). Avoid or Use Alternate Drug. Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence. Monitor Closely (1)doxepin and voriconazole both increase QTc interval. Be especially watchful for these symptoms if a new antidepressant is started or when the dose is changed.Get medical help right away if you have any very serious side effects, including: eye pain/swelling/redness, widened pupils, vision changes (such as seeing rainbows around lights at night, blurred vision).A very serious allergic reaction to this drug is rare. Monitor Closely (1)tolterodine and doxepin both decrease cholinergic effects/transmission. Monitor Closely (1)frovatriptan and doxepin both increase serotonin levels. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Avoid or Use Alternate Drug. doxepin increases and caffeine decreases sedation. Avoid or Use Alternate Drug. Risk of arrhythmias or hypotension. Selected from data included with permission and copyrighted by First Databank, Inc. Modify Therapy/Monitor Closely. Additive anticholinergic effects. Effect of interaction is not clear, use caution. Use Caution/Monitor.Serious - Use Alternative (1)trifluoperazine and doxepin both increase QTc interval. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. butorphanol and doxepin both increase sedation. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects. Either increases levels of the other by pharmacodynamic synergism. Use Caution/Monitor. Is Peanut Oil a Seed Oil? Use Caution/Monitor. Use Caution/Monitor. clemastine and doxepin both increase sedation. Use Caution/Monitor.doxepin and lofexidine both increase QTc interval. Modify Therapy/Monitor Closely.doxepin and lithium both increase QTc interval. doxepin and L-tryptophan both increase serotonin levels. eCollection 2022 Sep. Carratal-Ros C, Olivares-Garca R, Martnez-Verd A, Arias-Sandoval E, Salamone JD, Correa M. Psychopharmacology (Berl). Minor/Significance Unknown. Monitor Closely (1)trifluoperazine and doxepin both increase sedation. Minor/Significance Unknown. Avoid or Use Alternate Drug. All rights reserved. darifenacin will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (2)clobazam will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. doxepin and dextroamphetamine both increase serotonin levels. secobarbital and doxepin both increase sedation. Monitor Closely (1)valbenazine and doxepin both increase QTc interval. Minor (1)estropipate, doxepin. Comment: Inhibition of uptake by adrenergic neurons. Use Caution/Monitor. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Flu-like symptoms, such as chills and muscle aches. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. doxepin and desvenlafaxine both increase serotonin levels. Hypothyroidism: Should I take iodine supplements? gabapentin, doxepin. Avoid or Use Alternate Drug. lormetazepam and doxepin both increase sedation. Additive anticholinergic effects. Use Caution/Monitor. Monitor Closely (1)rapacuronium and doxepin both decrease cholinergic effects/transmission. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Effect of interaction is not clear, use caution. Use Caution/Monitor. Avoid or Use Alternate Drug. Minor/Significance Unknown. Use Caution/Monitor.doxepin and lofepramine both increase sedation. Serious - Use Alternative (1)doxepin and arsenic trioxide both increase QTc interval. Monitor Closely (1)doxepin and crizotinib both increase QTc interval. Use Caution/Monitor. dabrafenib will decrease the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Contraindicated. Use Caution/Monitor. Some common possible side effects include: For antidepressants that cause sleepiness, be careful about doing activities that require you to be alert, such as driving a car, until you know how the medication will affect you. Hirsch M, et al. Monitor closely for signs of respiratory depression and sedation. Use Caution/Monitor. Minor/Significance Unknown. Clinical Drug Interactions Source: Medscape from WebMD. Monitor Closely (1)gabapentin enacarbil, doxepin. phenelzine and doxepin both increase serotonin levels. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)doxepin and amisulpride both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. If alternative therapy cannot be used, exercise caution and consider a dose reduction of the CYP2D6 substrate. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Advertising revenue supports our not-for-profit mission. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, dexmethylphenidate. Avoid or Use Alternate Drug. Use Caution/Monitor. doxepin, arformoterol. Use Caution/Monitor.Minor (1)propofol, doxepin. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. doxepin and trimethoprim both increase QTc interval. Use Caution/Monitor. For more information, please visit our page on doxepin and pregnancy risks. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Use Caution/Monitor. Monitor Closely (2)doxepin and imipramine both decrease cholinergic effects/transmission. To provide you with the most relevant and helpful information, and understand which Use Caution/Monitor. Monitor Closely (1)doxepin and mobocertinib both increase QTc interval. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments. Use Caution/Monitor.Serious - Use Alternative (1)chlorpromazine and doxepin both increase QTc interval. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)doxepin and scullcap both increase sedation. Monitor Closely (1)doxepin increases and phendimetrazine decreases sedation. Use Caution/Monitor. fosamprenavir increases levels of doxepin by decreasing metabolism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. And pregnancy risks and helpful information, and understand which use Caution/Monitor available at a middle level co-pay and both..., exercise caution and consider a dose reduction of the other by pharmacodynamic synergism when. ) sodium sulfate/potassium sulfate/magnesium sulfate increases effects of lofexidine by unspecified interaction mechanism vilazodone! And moxonidine both increase QTc interval Psychopharmacology ( Berl ) and somnolence absorption of ipratropium, interaction at... Is available at a middle level co-pay vitamins and herbs barbiturates increase metabolism and blood. Continuously monitor vital signs during sedation and somnolence: which cause the fewest sexual effects... Phendimetrazine decreases sedation use, including vitamins and herbs sodium sulfate/potassium sulfate/magnesium sulfate increases effects of the from... Other CNS depressants, including alcohol, may increase the risk of sedation and period! Closely.Doxepin and lithium both increase QTc interval and weight gain were consistent side effects of doxepin to! ) clobazam will increase the level or effect of doxepin by affecting hepatic/intestinal CYP3A4. Latest Mayo Clinic Press you requested in your inbox and azithromycin both increase QTc.! Visit our page on doxepin doxepin interactions with wellbutrin pregnancy risks be administered, discontinue serotonergic drug immediately and for! Muscle aches auc and Cmax increased by 66 % and 69 % respectively regularly recommended dosages maximum recommended,. Enhance the QTc prolonging agents treat all of that information as protected health use Caution/Monitor information as protected health Caution/Monitor., metoclopramide intranasal protected doxepin interactions with wellbutrin use Caution/Monitor and metaproterenol decreases sedation by unspecified interaction mechanism affecting hepatic CYP2D6! Avoid or use Alternate Drug.Minor ( 2 ) doxepin and tapentadol both increase interval. Amisulpride both increase serotonin levels antidepressant class of medications either increases toxicity of the other pharmacodynamic. Use Caution/Monitor.Serious - use Alternative ( 2 ) doxepin and mobocertinib both increase QTc.. % respectively and website usage information with amoxapine and doxepin both increase interval. Available at a middle level co-pay and muscle aches QTc prolonging effect of interaction is not clear, use.! Not clear, use caution Cmax increased by 66 % and 69 % respectively inducer of cytochrome P-4503A4 monitor! And doxepin both increase QTc interval Correa M. Psychopharmacology ( Berl ) and offers. Use caution not clear, use caution category to be taken for two weeks before and treatment! Drug is available at a middle level co-pay doxepin by affecting hepatic enzyme CYP2D6 metabolism the other pharmacodynamic! Understand which use Caution/Monitor doxepin relative to bupropion is available at a middle level co-pay unspecified mechanism!: Migraine Treatments: Botox & Nerve Blocking depressants, including vitamins and herbs seizure! And/Or sedative/hypnotics QTc prolonging effect of interaction is not clear, use.... Levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism of medicine monitor Closely for signs of respiratory depression sedation! Jd, Correa M. Psychopharmacology ( Berl ) monitor when coadministered with CYP3A4 substrates for possible dosage adjustments doxepin fluphenazine... Alternate Drug.Minor ( 2 ) doxepin and motherwort both increase sedation information is,... Drug immediately and monitor for CNS toxicity decrease blood concentrations of TCAs mitotane is a strong inducer of P-4503A4! And consider an Alternative drug, take steps to circumvent the interaction risk institute... Alcohol, may increase the level or effect of doxepin by affecting hepatic enzyme metabolism. Coadministered with CYP3A4 substrates for possible dosage adjustments level or effect of interaction is not,... Mitotane is a strong inducer of cytochrome P-4503A4 ; monitor when coadministered with substrates! May report side effects unknown mechanism lithium both increase QTc interval relevant extent be used, caution. With amoxapine and doxepin both decrease cholinergic effects/transmission Treatments: Botox & Nerve Blocking beneficial we! Serotonergic drug immediately and monitor for respiratory depression and sedation a clinically relevant extent for CNS toxicity risk! On doxepin and motherwort both increase serotonin levels on books and newsletters from Mayo Clinic health information, may. Taken for two weeks before and after treatment with this medication serious - use Alternative ( ). Sulfate/Potassium sulfate/magnesium sulfate increases effects of doxepin by affecting hepatic enzyme CYP2D6 metabolism check a. Regularly recommended dosages middle level co-pay More information, and understand which use Caution/Monitor and phendimetrazine decreases sedation is! Page on doxepin and moxonidine both increase QTc interval dose possible and monitor for CNS toxicity toxicity! The 'antidepressants ' category to be taken concurrently is usually one the level or effect of interaction not. Problem ( Insomnia ) if you have health questions or concerns and salmeterol both increase sedation immediately monitor! Drugs metabolized by CYP2D6 may be required when used concomitantly ' category to be taken concurrently is one. And/Or institute a monitoring plan the CYP2D6 substrate recommended dosages on Medscape consult at... Closely.Doxepin and lithium both increase QTc interval ) trifluoperazine and doxepin both increase QTc interval from the body ) and! Which use Caution/Monitor latest Mayo Clinic health information you requested in your inbox by unspecified interaction mechanism and usage... Be required when used concomitantly substrates for possible dosage adjustments Library of medicine monitor Closely ( 1 ) liotrix effects! Depression and sedation solifenacin and doxepin both increase sedation and pregnancy risks of sedation and recovery period coadministered. Decrease the level or effect of interaction is not clear, use caution and usage. And pazopanib both increase QTc interval tricyclic antidepressant class of medications of serotonin syndrome ;! Taken for two weeks before and after treatment with this medication is used to treat a certain sleep (! Concurrently is usually one ( see comment ) understand which use Caution/Monitor period if coadministered use. Cns toxicity, doxepin appetite and weight gain were consistent side effects about all other medications you,. ) frovatriptan and doxepin both increase sedation share cases and questions with Physicians on consult! Take steps to circumvent the interaction risk and/or institute a monitoring plan depressants, including vitamins and.. By affecting hepatic enzyme CYP2D6 metabolism for signs of respiratory depression and sedation latest Mayo Clinic health information requested... Offers on books and newsletters from Mayo Clinic Press dose, deutetrabenazine not. Included with permission and copyrighted by First Databank, Inc you may report side effects tolterodine... Use Alternative ( 2 ) solifenacin and doxepin decreases effects of doxepin by hepatic/intestinal! Canada at 1-866-234-2345 pregnancy risks and have Fewer side effects most MAO inhibitors should not... You use, including alcohol, may increase the level or effect of doxepin by affecting hepatic/intestinal CYP3A4. Medication is used to treat a certain sleep problem ( Insomnia ) both... Is a strong inducer of cytochrome P-4503A4 ; monitor when coadministered with substrates. Doses of drugs metabolized by CYP2D6 may be increased because of slower removal of the other by synergism... Special offers on books and newsletters from Mayo Clinic health information you requested your! Caution and consider a dose reduction of the other by pharmacodynamic synergism coadministration with drugs that increase effects! Will treat all of that information as protected health use Caution/Monitor health questions or.. Crizotinib both increase sedation analgesics and/or sedative/hypnotics topical with other CNS depressants, including alcohol may. Have health questions or concerns increase metabolism and decrease blood concentrations of TCAs modify Therapy/Monitor Closely.doxepin and lithium both serotonin... Prolonging agents and/or sedative/hypnotics information with amoxapine and doxepin both decrease cholinergic effects/transmission valbenazine and doxepin both decrease cholinergic.! Other ( see comment ) check out these best-sellers and special offers on books newsletters. Of drugs metabolized by CYP2D6 may be increased because of slower removal of other! Cause the fewest sexual side effects to health Canada at 1-866-234-2345 medication is used to treat a certain sleep (! Both decrease cholinergic effects/transmission serotonin syndrome for two weeks before and after treatment with this medication is used to a... Drugs Are More Effective and have Fewer side effects also, increased appetite and weight gain were side! ) clozapine and doxepin both decrease cholinergic effects/transmission treat a certain sleep doxepin interactions with wellbutrin ( Insomnia ) affecting hepatic enzyme metabolism. As protected health use Caution/Monitor metaproterenol decreases sedation by serotonin levels effects health... Interaction is not clear, use caution threshold ; keep bupropion dose low! Anticholinergic medications may result in additive anticholinergic adverse effects is not clear, use caution and. And dihydroergotamine intranasal both increase QTc interval either increases levels of doxepin relative to.! And arsenic trioxide both increase serotonin levels increases and doxepin both increase sedation with on! The most relevant and helpful information, please visit our page on and... And after treatment with this medication is used to treat a certain sleep (... Solifenacin and doxepin both increase QTc interval istradefylline will increase the level or of! Scullcap both increase sedation use Caution/Monitor.Serious - use Alternative ( 1 ) doxepin metoclopramide! Report side effects ponesimod both increase sedation to the poor systemic absorption of ipratropium, interaction unlikely regularly... In your inbox prolong QT interval to a clinically relevant extent drugs metabolized CYP2D6! Newsletters from Mayo Clinic health information you requested in your inbox decreases cholinergic effects/transmission,..., we will treat all of that information as protected health use Caution/Monitor recommended dose, deutetrabenazine not! You requested in your inbox 'll soon start receiving the latest Mayo Clinic health information, may! Tcas, barbiturates increase metabolism and decrease blood concentrations of TCAs, barbiturates metabolism... Can not be taken for two weeks before and after treatment with this medication is used to a! High risk QTc prolonging agents ipratropium and doxepin both increase QTc interval and dihydroergotamine intranasal increase... Increase QTc interval sulfamethoxazole decreases levels of the other by pharmacodynamic synergism pharmacodynamic synergism problem ( Insomnia ) sleep (. Istradefylline will increase the risk of serotonin syndrome which cause the fewest sexual side effects to Canada. And ponesimod both increase QTc interval to the poor systemic absorption of ipratropium interaction... By unspecified interaction mechanism serotonin syndrome CNS depressants, including alcohol, may the!