For Items it increases by 2 coins * the number of purchases. Stat Down pills do nothing, and items like Experimental Treatment increase stats but don't reduce any, This effect works on items that apply negative stat modifiers, such as Soy Milk, This effect works for anything that gives temporary buffs, like Devil/Strength cards, or kill bonuses like Bloody Lust, If you somehow lose Rock Bottom, your stats will go back to normal, UNLOCK: Unlock this item by defeating the Boss Rush as Jacob & Esau, Bombs now explode with a random effect (e.g. Chapters red, drip, Isaac's health is set to 1 and he also gains 9 extra lives, Each time Isaac dies, he will respawn with 1 Health, Has a chance to drop from the Super Pride mini boss, The floating Dead Cat head that follows you will disappear when you are on your last life (Very useful for The Lost), Item Pool: Devil Room, Curse Room, Red Chest, Super Pride Miniboss, * curse room pool, red chest pool, red chest item pool, devil pool, devil room pool, devil deal, Gives Isaac demon wings and the ability to fly, * devil pool, devil room pool, devil deal, the lost item pool, cross, upside down, red, black. The following stats are applied to tears from Isaac's left eye only. More items consumed = more chance for this effect. If you get hit while Cursed eye is a solid black colour you are guaranteed to be teleported to another random room on the floor. pill) or picking up the Match Stick trinket, which will burn it off you, *, insect, bug, spider, beetle, grey, gray, brown, While held, this trinket gives Isaac a familiar that shoots piercing tears that deal 3.5 damage, UNLOCK: Unlock this item by beating the Boss Rush with Isaac, At the start of a new floor, you get an eternal heart, UNLOCK: Unlock this item by beating the Dark Room with Maggy, * , the lost item pool, cross, yellow, golden, glow, maggys faith, Items which cost 2 heart containers in a deal with the devil are reduced to only cost 1 heart, UNLOCK: Unlock this item by beating Satan with Judas, * , the lost item pool, tong, red, bloody, lips, judas tongue, Creates a familiar which moves around the room in a similar fashion to The Peeper, shooting tears in the same direction as Isaac, UNLOCK: Unlock this item by beating the Dark Room with Blue Baby, *, dead, baby, blue, ?? Items picked up are not shared between the two characters, UNLOCK: Unlock this item by defeating The Beast as Tainted Jacob, When activated, Isaac's tears are replaced by a bone sword and he goes on a killing rampage, gaining +0.4 Speed, +3 Flat Damage Up for 5 seconds, The sword deals x3 damage if used at close range, or x1.5 damage if charged up and thrown, Clearing rooms doesn't charge this item - charge is added equal to damage taken by enemies. Haemolacria is an unlockable passive item added in The Binding of Isaac: Afterbirth (Booster Pack #4). Eden - Spawns 3 items from any pools, you can only take 1, The Lost - Useless items like HP upgrades, spectral tears or flight are removed from the item pools, Lilith - Causes all your offensive familiars to stack tightly infront of Lilith for more controlled damage, Apollyon - Void has a chance to spawn a previously destroyed item as well. Blood clots can have d. Quality This doesn't work with The Lost characters, While in a room with enemies, red cracks will appear on the floor in random locations, Walking over the crack spawns a white soul familiar, that launches itself into the nearest enemy, exploding and dealing double your tear damage to everything near it, Cracks will keep appearing but only one can exist in the room at a time, UNLOCK: Unlock this item by defeating challenge #38 (Baptism by Fire), While held, this item spawns a familiar that can be moved around using the arrow keys and deals 1.5 damage per tick to any enemies it touches, When activated, you teleport, swapping places with wherever Stitches was positioned, Teleporting next to fires will extinguish them (including blue fires) and on top of shopkeepers will destroy them (gives +10% devil/angel room chance as normal), If used while stitches is on top of an enemy, it can be used to telefrag enemies, dealing x3.5 your damage + 40, Can be used to enter/exit Curse Rooms for free by teleporting infront of the door while holding the direction key to move in immediately. brown, brass, copper, dads key, dad key, * boss room pool, boss room item, item room, treasure room, item room pool, lumpy, red, balls, Using the portable slot takes a coin and has a chance to give a pickup - similar to how the normal slot machines work, REPENTANCE - The delay between uses was removed, allowing you to spam-use it, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, Every 40 seconds spent in the same room since last activating, when the timer displays 00, 20 or 40 seconds, a shield triggers, nullifying all types of damage for 10 seconds, As soon as Isaac has half a red heart or more, this item deactivates, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Lazarus, While firing tears this item gives you a chance to fire an eye across the screen with a very slow shot speed, which will fire tears of its own in the same direction as Isaac, The evil eye shots will be destroyed if they come into contact with enemies or obstacles, UNLOCK: Unlock this item by beating Greed Mode with Cain, Each time Isaac kills an enemy, you get a temporary +0.5 damage up which lasts for the current room, Each subsequent kill will stack further damage up to a maximum of +5 Damage Up after 10 kills, This item is the same principle as the Bloody Lust item from the original flash game, REPENTANCE - Added to the Devil Room pool, UNLOCK: Unlock this item by beating Greed Mode with Samson, Item Pool: Item Room, Devil Room, Greed Mode Item Room, After taking enough damage you will gain a permanent demon familiar, Possible familiars include: Dark Bum, Demon Baby, Leech, Lil' Brimstone, Succubus, Incubus, Lil Abaddon, Twisted Pair. This is a one-time use of the Red Key item. Items: Rocket in a Jar, Goat Head, Dead Cat, Soy Milk, Blood Clot. 2 keys = 16.6% chance. , 55 - . +0.5 tear falling speed. Item Pool: Item Room, Super Sloth Miniboss, Bomb Beggar, * boss rush pool, boss rush room, item room, treasure room, item room pool, bob sloth, ?, Satan and The Lamb as Tainted Lilith, All shops only sell familiars while holding this trinket, If you enter a shop while holding this trinket, the effect won't undo by dropping it until you move to a new floor, UNLOCK: Unlock this trinket by defeating Mother as Tainted Lilith, Every time an enemy dies you have a chance to gain a random Locust, Different color Locusts correspond to the horsemen. white, square, When used, you have a chance of getting one of the three following effects: Treasure Map (floor layout), Compass (map icons) or Blue Map (secret room locations), REPENTANCE - Book of Secrets now avoids giving mapping effects that the player already has. Pressing the bomb button will put the next poop into the 'Hold' jar. Bosses purple, An orbiting fly which deals 2 contact damage per tick to enemies, * item room, treasure room, item room pool, blue, Has a chance to drop from the Super Gluttony miniboss fight, Item Pool: Item Room, Super Gluttony Miniboss, * item room, treasure room, item room pool, the lost item pool, white, grey, gray, tub, Allows Isaac to fly while the Pony is held, Sets your speed stat to 1.5 if it isn't already that high, When the active attack is used, Isaac will dash across the screen dealing scaling contact damage to anything he hits, Drops from the Headless Horseman boss fight, REPENTANCE - A Pony's charge time has been reduced to 2 (from 4). item room pool, red, boom, tnt, * item room, treasure room, item room pool, wooden, cross, brown, Isaac can now hold two trinkets at the same time, Drops a random trinket on the floor when picked up, Allows you to pick up more trinkets while also holding The Tick, * shop room pool, shop item pool, purple, pink, bag, All of Isaac's bombs now leave a poison effect on any enemies within the blast radius, As well as dealing the standard 60 damage for a bomb, it will apply a Damage over Time effect that does 4 or 6 damage per tick, Has a chance to drop from the Super Sloth miniboss fight. UNLOCK: Unlock this item by defeating Lil Horn 20 times, When picked up, gives Isaac a random familiar which has a random sprite and tear effect, The familiar will be fully randomized again upon entering the next floor, The appearance is chosen from a random co-op baby sprite, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Ashkait and Scayze, A familiar that will transform into another random familiar every 10 seconds, copying their behaviour and effect, Can be any other familiar, including (but not limited to) Lil Brimstone, Bob's Brain, BBF, Meatboy, Rotten Baby, Familiars appear as a white Delirium version of the original, This item gives you 1 bar of charge on your active item for every 15 enemies you kill, Added as part of the Afterbirth+ Booster Pack #2 and based on the Steam Workshop mod created by Ashkait and Scayze, UNLOCK: Unlock this item by picking up any 3 of these items in a single run: 9 Volt, The Battery, Car Battery, AAA Battery, Watch Battery, When used, the coupon causes one random item in the shop to become free, While held, guarantees a random item or pickup from the shop to be half price, The effect of this item also works in Devil Rooms, allowing you to take one random item for free, Added as part of the Afterbirth+ Booster Pack #2 and based on the Steam Workshop mod created by Plumbo, *, paper, square, green, pink, white, barcode, letter, postcard, An active that causes all enemy tears to be held in place and then thrown back away from Isaac for a period of 3 seconds, The aura from this item will repel nearby enemies, Added as part of the Afterbirth+ Booster Pack #2, When used, the box will pick up a maximum of 6 items. Challenges (Does not change your trinkets, pills or cards), 2 Dot - Rerolls all pickups in the room. Well Cain is supposed to be lucky right? They do not block enemy shots, UNLOCK: Unlock this item by defeating The Beast as Tainted Lilith, Isaac builds rage each time you clear a new room. The most common signs are crushing chest pain and difficulty breathing. Modes syringe, needle, injection, purple, grey, gray, Causes Isaac to shrink in size (including hitbox slightly), Can be dropped when exploding mushrooms in the environment that are usually found in the Caves/Catacombs and in secret rooms, * item room, treasure room, item room pool, mushroom, blue, spotted, Adds several instances of The Bible item into all item pools. Brimstone is actually one of the best items, combine that with brimsnapping and it being very accesible due to being a common item in Devil Rooms and you get yourself a loyal safety net. blood clot es un aumento de dao parcial debido a que no solo una de dos lagrimas disparadas tengan mas dao este item es de la pool de habitacion del tesoro , bosses o por el item de polyp este item se aprobecha mas con el item de 20.20 ya que en este caso las probabilidades de que mas de una sola lagrima tenga ese aumento de dao Completion Marks Blood Bag) it will be rerolled into a random Item Room item, Cannot remove Azazel's Brimstone laser, or The Lost's Holy Mantle, REPENTANCE - Full run reroll effects are now able to remove heart containers and transformations if losing the respective items during the reroll, UNLOCK: Unlock this item by blowing up 30 slot machines, * item room, treasure room, item room pool, dice pip, starting, pyramid, green, triange, When used, 'devolves' all enemies in the room which are currently alive into another weaker type of enemy, * item room, treasure room, item room pool, DIO, dice pip, orange, brown, turban, When used, copies the effect of the card you are currently holding without consuming it, The charge time of this item depends on the quality of the card you're holding, Using this with the ? ( : Bum Friend The Peeper Ghost Baby Harlequin Baby Daddy Longlegs Sacrificial Dagger Rainbow Baby Holy Water Guppy's Hair Ball Abel), Others: 1UP The Virus Less Than Three Skeleton Key A Dollar A Quarter Boom! Lil Clot spawns in a random location near Isaac when the trinket is first picked up. Brimstone Bombs: Brimstone beams will shoot out upon exploding. Corpse II drops same as Womb II, UNLOCK: Unlock this item by beating the Dark Room with Lazarus, * red chest pool, red chest item pool, shop room pool, shop item pool, blue box, pandoras box, When used, turns Isaac invincible and gains +0.28 speed for a 5 seconds, You cannot fire tears while the stump is active, Very similar to the My Little Unicorn item but does not deal contact damage, When used with Mom's Knife, you can still deal contact damage but will be unable to change the way the knife faces while the effect is active, * item room, treasure room, item room pool, white, lump, grey, gray, blob, While in a hostile room your speed raises at a rate of +0.065 per game tick, When you hit a speed stat of 2.0, Isaac will gain an invincibility effect for 5 seconds, increasing speed and allowing him to run into enemies to deal 40 contact damage per hit, The time it takes for the effect to activate becomes shorter with a higher base Speed stat, * astrology, astronomy, item room, treasure room, item room pool, blue, glow, circle, horns, Gives huge horns which stick out, allowing you to deal 18 contact damage if you hit something with enough speed, Will not deal contact damage unless you are moving fast enough (at least 0.8 speed), REPENTANCE - Aries now prevents receiving contact damage if ramming and killing enemies at full speed, * astrology, astronomy, item room, treasure room, item room pool, black, blue, cyan, glow, After getting hit once, you gain a damage reduction for the rest of the room similar to The Wafer item (-50% damage taken), * astrology, astronomy, item room, treasure room, item room pool, cyan, black, the lost item pool, A familiar baby that fires tears which have a chance to freeze or petrify enemies, Counts as 1 of 3 familiar items needed towards the Conjoined transformation, When used, rerolls all items in the room into another random item from the current room's item pool, however the item also has a 30% chance to disappear, The chance associated with this item does NOT scale with your Luck stat - it's always 30%, In the game files this item is called 'Florians Dice', which is a reference to the Eternal update for the original Binding of Isaac game, which changed the D6 to act as this item does. Devil Rooms / I AM ERROR rooms, UNLOCK: Unlock this item by defeating Mother as Apollyon, You gain a familiar that lives under the floor. 00:00. 4 Those tears will cause the same effect if they happen to hit other enemies, Effects that replace your tears such as Brimstone simply have a chance to apply this effect, Any enemies that come within close range of Isaac will become feared, which causes them to flee, When used, this item takes away 5 of your coins and gives a +1.2 Damage Up that lasts for the current room, Can stack as many times as you want. Even if Isaac have not finished charging Brimstone when he'll pass through a door, it is always fully charged once a new room is entered if the fire button is still being held. 68 . Blood clotting becomes a problem when it blocks your blood . This means some effects such as R U A WIZARD pills only fire tears in one direction, When used, you charge forwards for a second. * secret room pool, item room, treasure room, item room pool, 25, grey, gray, silver, devil pool, devil room pool, devil deal, Converts most negative pills into their positive counterparts, e.g. Challenges mario, cartridge, nes, grey, gray, orange, When used, rerolls each item you currently own into another item room pool item and any pedestal items and pickups in the room, Has the combined uses of the D4, D6 and D20, REPENTANCE - Full run reroll effects (such as D4) are now able to remove heart containers and transformations if losing the respective items during the reroll, UNLOCK: Unlock this item by beating Boss Rush with The Lost, * item room, treasure room, item room pool, deathstar, death star, dice pip, white, circle, sphere, When used, the D4 re-rolls each item you currently have into another random item from the same item pool, If you have an item with no room pool (e.g. now allows the player to influence the teleport direction (using the direction Isaac is moving upon activating the item), * item room, treasure room, item room pool, blue remote, robot, When used as the Keeper, one coin HP is restored, Has a chance to drop from the Super Lust miniboss fight, Item Pool: Item Room, Super Lust Miniboss, * item room, treasure room, item room pool, the lost item pool, maggy, starting, Haemolacria is an unlockable passive item added in the room items: Rocket in a Jar Goat... 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